Estradiol (E2) Test
An estradiol test measures the most potent form of estrogen in the blood to assess reproductive health, fertility, and hormonal balance.
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LevelPanel has no business or affiliate relationship with Quest or LabCorp. These links are provided as a public service.
Lab testing services linked from this site are not available to residents of Alaska, Arizona, or Hawaii, unless otherwise noted on the lab's own website.
This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.
What this test measures
Estradiol (E2) is the most potent and biologically active form of estrogen. While primarily associated with female reproductive health, estradiol serves important functions in both sexes, contributing to bone metabolism, cardiovascular protection, nervous system maturation, and fat distribution. In women, the ovaries are the primary production site; in men, the testes produce smaller amounts. Both sexes also generate estradiol in the adrenal glands and fat tissue.
This test measures serum estradiol concentration and is a central tool for evaluating reproductive function. In women, it helps assess menstrual irregularities, infertility, and menopausal status. In men, estradiol testing can reveal whether excessive conversion of testosterone to estrogen is occurring, which may affect hormonal balance. Beyond reproduction, estradiol supports bone density and joint health in both sexes, making it relevant for evaluating skeletal health as well. The test provides insight into whether estradiol levels are within the expected range for a given age and clinical context.
Who should consider this test
You might consider this test if you are experiencing any of the following:
- Women experiencing irregular menstrual periods, heavy bleeding, or missed periods who want to understand their hormonal balance
- Individuals struggling with fertility issues or difficulty conceiving who need to assess reproductive hormone levels
- Women going through menopause or perimenopause experiencing symptoms like hot flashes, mood changes, or sleep disturbances
- Men experiencing unexplained symptoms like decreased energy, mood changes, or concerns about bone health
- People with symptoms that may indicate hormonal imbalances such as unexpected weight changes or changes in sex drive
- Individuals monitoring hormone replacement therapy or fertility treatments who need to track estradiol levels
What to expect
Preparation
No special preparation is needed for this test. You can eat normally and take medications as prescribed. However, inform your healthcare provider about any hormone medications or supplements you're taking.
Sample Type
A simple blood draw from a vein in your arm, similar to routine blood work
Collection
Visit any LabCorp location with your test order. Present a valid ID and have your blood drawn by a trained technician. The process takes just a few minutes.
Turnaround
Results are typically available within 1-3 business days and will be delivered securely to your online account
Understanding your results
Estradiol levels shift substantially across the lifespan and, in women of reproductive age, fluctuate dramatically within each menstrual cycle. For this reason, the timing of the blood draw relative to the cycle phase significantly affects the result and its interpretation. Reference ranges are stratified by age and sex, and the lab report will specify which ranges apply. Healthcare providers evaluate estradiol alongside symptoms and, when appropriate, other reproductive hormones (such as FSH and LH) to distinguish normal hormonal variation from clinically meaningful imbalances.
| Population | Reference Range | Notes |
|---|---|---|
| Premenopausal women (follicular phase) | 30-100 pg/mL | Levels vary throughout menstrual cycle |
| Premenopausal women (mid-cycle peak) | 100-400 pg/mL | Peak occurs around ovulation |
| Postmenopausal women | < 10-30 pg/mL | Significantly lower after menopause |
| Adult men | 10-40 pg/mL | Relatively stable throughout adult life |
Reference ranges shown are general guidelines. Your lab report will include the specific reference range used by the laboratory that processed your sample, which is the authoritative range for interpreting your results.
What does a “Low” result mean?
Low estradiol levels in women may suggest hypogonadism, ovarian dysfunction, or menopause. Very low levels in postmenopausal women and older men may be associated with increased risk of osteoporotic fractures.
What does a “High” result mean?
Elevated estradiol levels may indicate conditions such as polycystic ovarian syndrome, estrogen-producing tumors, or certain ovarian disorders. In men, higher than normal levels can be associated with conditions affecting hormone balance or metabolism.
Privacy & confidentiality
Your estradiol test results are completely confidential and delivered securely through your private online account. Results are never shared with employers, insurance companies, or other third parties without your explicit consent. We understand that hormone testing can feel personal, and we're committed to protecting your privacy throughout the entire process.
Frequently asked questions
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Last reviewed: April 2026
CPT Code: 82670
This test may not be available in: NY, NJ, RI
This page is for informational purposes only and does not constitute medical advice. Always consult with a healthcare provider regarding any health concerns. LevelPanel does not diagnose, treat, or prescribe.
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LevelPanel has no business or affiliate relationship with Quest or LabCorp. These links are provided as a public service.
Lab testing services linked from this site are not available to residents of Alaska, Arizona, or Hawaii, unless otherwise noted on the lab's own website.
This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.
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