Fatigue Panel (CBC, CMP, TSH, Iron, B12, Vitamin D)
Comprehensive blood panel to identify common causes of chronic tiredness including anemia, thyroid dysfunction, iron deficiency, and vitamin deficiencies.
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LevelPanel has no business or affiliate relationship with Quest or LabCorp. These links are provided as a public service.
Lab testing services linked from this site are not available to residents of Alaska, Arizona, or Hawaii, unless otherwise noted on the lab's own website.
This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.
What this test measures
The Fatigue Panel targets the most common medical explanations for persistent tiredness by testing six areas that directly influence energy production and regulation: blood cell health (CBC), organ and metabolic function (CMP), thyroid activity (TSH), iron stores, vitamin B12, and vitamin D.
Standard annual screenings often skip several of these markers, which means conditions like early iron depletion, subclinical thyroid dysfunction, or vitamin deficiency can go undetected for months or years. Each of these imbalances can impair energy metabolism at the cellular level, producing fatigue that persists even when sleep and lifestyle habits seem adequate. By consolidating these tests into a single panel, the Fatigue Panel provides a broader diagnostic starting point than a routine blood draw and helps identify treatable causes that more basic testing may overlook.
What's included
Who should consider this test
You might consider this test if you are experiencing any of the following:
- Individuals experiencing persistent fatigue, tiredness, or low energy levels lasting more than a few weeks
- Those with difficulty concentrating, brain fog, or mental fatigue that interferes with daily activities
- People who feel tired despite getting adequate sleep or rest
- Individuals with symptoms that may suggest thyroid dysfunction, such as unexplained weight changes, hair loss, or temperature sensitivity
- Those at risk for iron deficiency, including individuals with heavy menstrual periods, vegetarians, or those with digestive issues
- People following restricted diets or those concerned about vitamin deficiencies
- Athletes or active individuals experiencing decreased performance or unusual fatigue during exercise
What to expect
Preparation
Fasting for 8-12 hours is recommended before testing to ensure accurate glucose and lipid measurements in the comprehensive metabolic panel. Certain supplements and medications can interfere with test results, so individuals should consult with their healthcare provider about temporarily stopping supplements if concerned about potential interference. Water is generally permitted during the fasting period.
Sample Type
A standard blood draw from a vein in the arm, typically taking just a few minutes to collect the necessary sample.
Collection
Visit any participating laboratory location for a quick blood draw. The sample will be processed to measure all six components of the fatigue panel using established laboratory methods.
Turnaround
Results are typically available within 1-3 business days and will be accessible through a secure online portal or provided according to the laboratory's standard reporting procedures.
Understanding your results
The panel's value lies in how the results connect to one another. The CBC can reveal anemia or abnormal blood cell counts, the CMP flags metabolic or organ-function issues, TSH reflects thyroid regulation, iron studies show whether reserves are depleted, and vitamin B12 and D levels indicate whether key nutritional building blocks are available for energy production. Healthcare providers typically read these results as a set, since fatigue frequently stems from more than one contributing factor acting simultaneously.
| Population | Reference Range | Notes |
|---|---|---|
| Adult Males - TSH | 0.4-4.5 mIU/L | Normal thyroid function range for most healthy adult males |
| Adult Females - TSH | 0.4-4.5 mIU/L | Normal thyroid function range for most healthy adult females |
| Adults - Vitamin B12 | 200-950 pg/mL | Some experts recommend levels above 500 pg/mL for optimal function |
| Adults - Vitamin D | 20-100 ng/mL, with 30-100 ng/mL considered optimal | Levels below 20 ng/mL are considered deficient |
| Adult Males - Ferritin | 30-566 ng/mL | Iron storage protein levels in healthy adult males |
| Adult Females - Ferritin | 15-205 ng/mL | Iron storage protein levels in healthy adult females |
Reference ranges shown are general guidelines. Your lab report will include the specific reference range used by the laboratory that processed your sample, which is the authoritative range for interpreting your results.
What does a “Low” result mean?
Low TSH levels may indicate an overactive thyroid with symptoms like weight loss and rapid heart rate, while high TSH often suggests an underactive thyroid characterized by fatigue and cold intolerance. Low vitamin B12 levels (typically below 200-250 pg/mL) may indicate deficiency, which can cause fatigue, anemia, and neurological symptoms. Vitamin D levels below 20 ng/mL are considered deficient and may contribute to fatigue, mood changes, and weakened immunity. Low ferritin combined with low blood counts typically indicates iron-deficiency anemia, which is a common and treatable cause of chronic fatigue.
What does a “High” result mean?
Elevated TSH levels typically indicate an underactive thyroid (hypothyroidism), where the pituitary gland produces extra TSH to compensate for insufficient thyroid hormone production. High ferritin levels may indicate iron overload, inflammation, or conditions like hemochromatosis, and can also occur due to infections or autoimmune diseases. Elevated vitamin D levels are uncommon but may result from excessive supplementation. High values in the CBC or CMP components may suggest various underlying conditions that warrant further evaluation by a healthcare provider.
Privacy & confidentiality
All test orders are authorized and results reviewed by an independent, board-certified physician who is not the patient's personal doctor. LevelPanel understands that health testing can be a deeply personal matter, and individuals value discretion when investigating symptoms like chronic fatigue. Your Fatigue Panel results are handled with complete confidentiality and <u>not reported to your doctor</u> unless you choose to share them. The test results are <u>not added to your medical records</u> automatically, giving you full control over your health information. Additionally, since this is a direct-pay service, the test <u>will not appear on insurance statements</u> or explanations of benefits, ensuring your privacy is maintained. Many people prefer the privacy of direct lab testing when exploring potential causes of fatigue, especially when they want to rule out common issues before seeing a healthcare provider. Your results are delivered securely through an encrypted online portal, accessible only to you. LevelPanel does not share your information with employers, insurance companies, or anyone else without your explicit consent. This confidential approach allows individuals to take charge of their health investigation while maintaining complete discretion about their testing and results.
Frequently asked questions
Related tests
Comprehensive Thyroid Panel
Provides more detailed thyroid evaluation including Free T4 and Free T3 if TSH is abnormal
View TestComplete Iron Studies Panel
Offers comprehensive iron assessment including TIBC and transferrin saturation if iron deficiency is suspected
View TestB-Complex Vitamin Panel
Evaluates other B vitamins that can contribute to fatigue if B12 deficiency is identified
View TestRelated conditions
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Last reviewed: April 2026
CPT Code: 85025, 80053, 84443, 82728, 82607, 82306
This test may not be available in: NY, NJ, RI
This page is for informational purposes only and does not constitute medical advice. Always consult with a healthcare provider regarding any health concerns. LevelPanel does not diagnose, treat, or prescribe.
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LevelPanel has no business or affiliate relationship with Quest or LabCorp. These links are provided as a public service.
Lab testing services linked from this site are not available to residents of Alaska, Arizona, or Hawaii, unless otherwise noted on the lab's own website.
This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.
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