DHEA-Sulfate
Measures DHEA-sulfate levels to assess adrenal gland function and help diagnose hormonal imbalances.
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Lab testing services linked from this site are not available to residents of Alaska, Arizona, or Hawaii, unless otherwise noted on the lab's own website.
This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.
What this test measures
DHEA-sulfate (DHEA-S) is a steroid hormone produced predominantly by the adrenal glands, with smaller contributions from the testes in men and the ovaries in women. It serves as a precursor hormone, meaning the body converts it into more potent androgens (such as testosterone and androstenedione) and estrogens as needed. In this way, DHEA-S functions as a hormonal reservoir that the body draws from to maintain sex hormone balance.
DHEA-S levels follow a distinctive age-related curve: they rise sharply during puberty, peak in early adulthood, and then decline gradually over subsequent decades. Unlike many hormones that pulse or fluctuate significantly throughout the day, DHEA-S remains relatively stable in the bloodstream, which makes it a reliable single-draw marker for assessing adrenal function and overall androgen status. This test measures the circulating concentration of DHEA-S and is commonly ordered when healthcare providers are evaluating adrenal gland performance, investigating signs of androgen excess (such as acne or abnormal hair growth), or assessing hormonal changes associated with aging.
Who should consider this test
You might consider this test if you are experiencing any of the following:
- Individuals with symptoms of hormone imbalances, including excess hair growth (hirsutism), severe acne, irregular menstrual periods, or fertility concerns
- Those experiencing unexplained fatigue, low energy, decreased sex drive, or other symptoms that may indicate adrenal dysfunction
- Women being evaluated for polycystic ovary syndrome (PCOS) or other conditions causing elevated androgen levels
- Patients with suspected adrenal gland disorders, including those who may have adrenal tumors or congenital adrenal hyperplasia
- Individuals with early or delayed puberty requiring evaluation of adrenal function
- Those being monitored for Addison's disease, hypopituitarism, or other conditions affecting hormone production
What to expect
Preparation
No special preparation is necessary. However, tell your health care provider if you are taking any vitamins or supplements that contain DHEA or DHEA-sulfate. The test can be performed at any time of day since DHEA-sulfate levels remain stable throughout the day.
Sample Type
A blood sample is drawn from a vein in the arm
Collection
A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
Turnaround
Results are typically available within 2-3 business days
Understanding your results
DHEA-S results are interpreted in the context of age and sex, since the expected range shifts substantially across the lifespan. Levels that would be normal for a 25-year-old may be well above the expected range for a 60-year-old. Abnormal results may point to adrenal dysfunction or an imbalance in sex hormone production, but healthcare providers consider clinical symptoms, other hormone levels, and medical history before drawing conclusions. A single elevated or depressed reading typically prompts further evaluation rather than an immediate diagnosis.
| Population | Reference Range | Notes |
|---|---|---|
| Adult Males (18-29 years) | 80-560 µg/dL | Values vary by laboratory and testing method |
| Adult Females (18-29 years) | 35-430 µg/dL | Values vary by laboratory and testing method |
| Adults (30-39 years) | Males: 80-560 µg/dL, Females: 35-430 µg/dL | Levels begin to decline after age 30 |
| Adults (40+ years) | Progressively lower with advancing age | Normal age-related decline expected |
Reference ranges shown are general guidelines. Your lab report will include the specific reference range used by the laboratory that processed your sample, which is the authoritative range for interpreting your results.
What does a “Low” result mean?
Low levels of DHEAS also may require further testing. They can be a sign of problems including: Addison's disease. Pituitary adenomas, including hypopituitarism. If your results show low levels of DHEAS, it may be a sign of the following conditions: Addison disease. Addison disease is a disorder in which the adrenal glands are not able to make enough of certain hormones. Hypopituitarism, a condition in which the pituitary gland does not make enough of one or more of the pituitary hormones. Low levels of DHEAS can cause sexual dysfunction, such as low sex drives (libido), in all sexes. Men may experience erectile dysfunction. Low DHEA levels often present symptoms such as memory loss, fatigue, low libido, osteoporosis and erectile dysfunction in men. Low DHEA levels often present symptoms such as memory loss, fatigue, low libido, osteoporosis and erectile dysfunction in men.
What does a “High” result mean?
High levels of DHEAS may mean you need additional testing. They can indicate problems such as: Polycystic ovary syndrome (PCOS). Cancerous or noncancerous adrenal tumors, including adrenocortical carcinoma. Congenital adrenal hyperplasia. Ovarian cancer. PCOS is one of the more common causes of elevated DHEA in women. Around 20 to 30% of women with PCOS have excess DHEA-S production from the adrenal glands, leading to hyperandrogenism or high androgen hormones, including testosterone and the potent androgen dihydrotestosterone (DHT). Elevated levels may also be associated with symptoms such as abnormal menstruation, including amenorrhea (missed periods). Excessive hair growth (hirsutism). Hair loss in women. Infertility. Severe acne. It's important to note that additional testing is typically needed to determine the specific cause of elevated DHEA-sulfate levels.
Privacy & confidentiality
All test orders are authorized and results reviewed by an independent, board-certified physician who is not the patient's personal doctor. When individuals order DHEA-sulfate testing through LevelPanel, complete confidentiality is maintained throughout the entire process. Test results are <u>not reported to your doctor</u> unless you specifically choose to share them, ensuring that hormone testing remains completely private. The results are <u>not part of your medical records</u> and will not appear on insurance statements or Explanation of Benefits (EOB), providing peace of mind for those who prefer to keep their hormonal health information confidential. This private testing approach is particularly valuable for individuals who want to monitor their adrenal function or investigate hormonal concerns without involving their primary healthcare provider initially. Whether someone is experiencing symptoms like fatigue, irregular periods, or other hormonal imbalances, they can obtain comprehensive DHEA-sulfate testing with complete discretion. The secure online platform ensures that sensitive health information remains protected, and individuals maintain full control over who has access to their hormonal health data.
Frequently asked questions
Related tests
Testosterone Test
Often tested together since DHEA-sulfate converts to testosterone and both are important androgens
View TestCortisol Test
Both hormones are produced by the adrenal glands and help assess overall adrenal function
View TestComprehensive Hormone Panel
DHEA-sulfate is typically included in comprehensive panels for evaluating hormonal imbalances
View TestRelated conditions
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Last reviewed: April 2026
CPT Code: 82627
This test may not be available in: NY, NJ, RI
This page is for informational purposes only and does not constitute medical advice. Always consult with a healthcare provider regarding any health concerns. LevelPanel does not diagnose, treat, or prescribe.
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LevelPanel has no business or affiliate relationship with Quest or LabCorp. These links are provided as a public service.
Lab testing services linked from this site are not available to residents of Alaska, Arizona, or Hawaii, unless otherwise noted on the lab's own website.
This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.
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